ARG30255
IKB alpha degradation Antibody Panel (IKK alpha, IKK beta, IKB alpha)
Cancer antibody; Cell Biology and Cellular Response antibody; Gene Regulation antibody; Immune System antibody; Signaling Transduction antibody
参考文献1
内含物
| 货号 | 内含物名称 | 宿主克隆性 | 反应 | 应用 | 包装 |
|---|---|---|---|---|---|
| ARG54650 | anti-IKK alpha antibody | Rabbit pAb | Hu | ELISA, ICC/IF, WB | 25 μg |
| ARG54686 | anti-IKK beta antibody | Rabbit pAb | Hu | ELISA, ICC/IF, WB | 25 μg |
| ARG54710 | anti-IKB alpha antibody | Rabbit pAb | Hu, Ms, Rat | WB | 50 μl |
| ARG65351 | Goat anti-Rabbit IgG antibody (HRP) | Goat pAb | Rb | ELISA, IHC-P, WB | 50 μl |
概述
| 产品描述 | Rel or NF-kappaB (NF-kB) proteins comprise a family of structurally-related eukaryotic transcription factors that are involved in the control of a large number of normal cellular and organismal processes, such as immune and inflammatory responses, developmental processes, cellular growth, and apoptosis. Once activated, IκB proteins are phosphorylated by IKKα and IKKβ, leading to the degradation of IκB proteins and nuclear translocation of NF-κB proteins. Hence, up-regulation of phospho-IKKα, phospho-IKKβ and down-regulation of IkB alpha is often associated with the activation of NF-kB downstream signaling pathway. Hayden and Ghosh. (2012) Genes and Dev 26: 203-234 Baeuerle and Henkel. (1994) Ann Rev Immunol 12: 141-179 |
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| 靶点名称 | IKB alpha degradation |
| 別名 | IKB alpha degradation antibody; IKK alpha antibody; IKK beta antibody; IKB alpha antibody |
属性
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
|---|---|
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 全名 | Antibody Panel for IKB alpha degradation (IKK alpha, IKK beta, IKB alpha) |
|---|---|
| 产品亮点 | Related Product: anti-IKK beta antibody; anti-IKB alpha antibody; |
| 研究领域 | Cancer antibody; Cell Biology and Cellular Response antibody; Gene Regulation antibody; Immune System antibody; Signaling Transduction antibody |
检测图片 (10) Click the Picture to Zoom In
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ARG54650 anti-IKK alpha antibody WB image
Western blot: 30 μg of HeLa cell lysates 1) untreated or 2) treated with 5 ng/ml TNF-a for 5 min, stained with ARG54650 anti-IKK alpha antibody at 1:500 dilution.
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ARG54686 anti-IKK beta antibody WB image
Western blot: 30 μg of HeLa cell lysates 1) untreated or 2) treated with 5 ng/ml TNF-a for 5 min, stained with ARG54686 anti-IKK beta antibody at 1:500 dilution.
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ARG54710 anti-IKB alpha antibody WB image
Western blot: 30 µg of HeLa cells treated with 5, 10 or 20 ng/ml of TNF alpha at 10, 20 or 30 mins. The blots were stained with ARG54710 anti-IKB alpha antibody at 1:500 dilution. The ARG10112 anti-GAPDH antibody [6C5] was used as loading control.
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ARG54650 anti-IKK alpha antibody ICC/IF image
Immunocytochemistry: Jurkat cells stained with ARG54650 anti-IKK alpha antibody at 1μg/ml.
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ARG54650 anti-IKK alpha antibody ICC/IF image
Immunofluorescence: Jurkat cells stained with ARG54650 anti-IKK alpha antibody at 10 μg/ml.
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ARG54686 anti-IKK beta antibody ICC/IF image
Immunocytochemistry: HeLa cells stained with ARG54686 anti-IKK beta antibody at 10 μg/ml.
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ARG54686 anti-IKK beta antibody ICC/IF image
Immunofluorescence: Hela cells stained with ARG54686 anti-IKK beta antibody at 10 μg/ml.
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ARG65351 Goat anti-Rabbit IgG antibody (HRP) WB image
Western blot: Rat placental stained with ARG57589 anti-MTNR1A antibody at 1:1000 dilution, ARG65351 Goat anti-Rabbit IgG antibody (HRP) at 1:5000 dilution.
From Jinzhi Li et al. J Reprod Immunol. (2023), doi: 10.1016/j.jri.2023.104166, Fig. 2.B.
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ARG65351 Goat anti-Rabbit IgG antibody (HRP) WB image
Western blot: Mouse retina stained with ARG65693 anti-alpha Tubulin antibody and ARG65351 Goat anti-Rabbit IgG antibody (HRP)
From Xiaoyuan Ye et al. Mol Ther Nucleic Acids. (2024), doi: 10.1016/j.omtn.2024.102209, Fig. 5.D.
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ARG65351 Goat anti-Rabbit IgG antibody (HRP) IHC-P image
From Yu-Qian Song et al. J Mol Med (Berl) (2022), doi: 10.1007/s00109-021-02165-0, Fig. 5.c.
文献引用
Caffeic acid phenethyl ester down-regulates claudin-2 expression at the transcriptional and post-translational levels and enhances chemosensitivity to doxorubicin in lung adenocarcinoma A549 cells
ARG54710: WB / Human
